解聚蛋白样金属基质蛋白酶-7在心血管疾病治疗新靶点中的研究进展

杨嵩, 宫丽丽, 刘丽宏

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (18) : 1536-1540.

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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (18) : 1536-1540. DOI: 10.11669/cpj.2018.18.002
综述

解聚蛋白样金属基质蛋白酶-7在心血管疾病治疗新靶点中的研究进展

  • 杨嵩, 宫丽丽*, 刘丽宏*
作者信息 +

ADAMTS-7—A New Target for Cardiovascular Diseases Treatment

  • YANG Song, GONG Li-li*, LIU Li-hong*
Author information +
文章历史 +

摘要

解聚蛋白样金属基质蛋白酶(a disintegrin-like and metalloprotease,ADAMTS)是含有I型血小板结合蛋白基序的多结构域分泌型蛋白。含有Ⅰ型血小板结合蛋白基序的ADAMTS-7为ADAMTS家族重要一员,在心血管疾病中扮演着重要的角色。ADAMTS-7在生理状态下参与机体的生长发育,病理状态ADAMTS-7过表达,通过降解软骨寡聚基质蛋白(COMP)等细胞外基质从而参与多种心血管疾病的发生发展。同时转化生长因子(TGF)-β、miRNA29a/b可以有效的抑制ADAMTS-7的过表达,进而有效抑制心血管疾病的发展。笔者主要对ADAMTS-7的基因结构、蛋白功能及其在心血管涉及的作用机制进行回顾阐述,并展望ADAMTS-7作为治疗心血管疾病新靶点的可能性。

Abstract

A disintegrin-like and metalloprotease(ADAMTS) proteinases are a group of multidomains and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the cardiovascular diseases. In physically, ADAMTS-7 was involved in the growth and development of the body. However, in pathological conditions, over expression of ADAMTS-7 gene accelerated the progression of cardiovascular diseases through by promoting the breakdown of cartilage oligomeric matrix protein (COMP) matrix. Meantime, the over expression of ADAMTS-7 can be effectively inhibited by TGF-β, miRNA29a/b, and then effectively retarded the development of cardiovascular disease. This article mainly reviews the gene structure, protein function and the mechanism of ADAMTS-7 involved in cardiovascular diseases and looks forward to the possibility of ADAMTS-7 as a new target for the treatment of cardiovascular diseases.

关键词

解聚蛋白样金属基质蛋白酶-7 / 软骨寡聚基质蛋白 / 金属蛋白酶 / 心血管疾病

Key words

ADAMTS-7 / COMP / metalloproteinase / cardiovascular diseases

引用本文

导出引用
杨嵩, 宫丽丽, 刘丽宏. 解聚蛋白样金属基质蛋白酶-7在心血管疾病治疗新靶点中的研究进展[J]. 中国药学杂志, 2018, 53(18): 1536-1540 https://doi.org/10.11669/cpj.2018.18.002
YANG Song, GONG Li-li, LIU Li-hong. ADAMTS-7—A New Target for Cardiovascular Diseases Treatment[J]. Chinese Pharmaceutical Journal, 2018, 53(18): 1536-1540 https://doi.org/10.11669/cpj.2018.18.002
中图分类号: R965   

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基金

北京市自然科学基金面上项目资助(7172085);北京市医院管理局“青苗”计划专项经费资助(QML20150302)
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